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Given that PS on the cell surface may trigger several reactions, this abnormality may contribute to the erythrocyte pathology commonly encountered in chronic uremia, including ionic transport defects, osmotic alterations, deformations, fragility, and coagulation abnormalities

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The most significant reaction of mevalonate pathway, which represents the rate-limiting reaction, is catalyzed by 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR